Nanostructured mixed Ni/Pt hydroxides electrodes for BIA-amperometry determination of hydralazine

• Published in: Journal of the Taiwan Institute of Chemical Engineers 2019-02, Vol.95, p.475-480
• Main Authors: Azeredo, Nathália F.B., Rossini, Pamela O., Gonçalves, Josué M., Assis, Geovanne L., Araki, Koiti, Angnes, Lúcio
• Format: Article
• Language: English
• Subjects: Batch injection analysis; Hydralazine; Modified FTO electrodes; Ni/Pt hydroxide nanoparticles
• ISSN: 1876-1070; 1876-1089
• DOI: 10.1016/j.jtice.2018.08.033

A fluorine doped tin oxide (FTO) coated glass modified with mixed nickel/platinum hydroxide nanoparticles (α-Ni0.98Pt0.02(OH)2) was utilized as BIA amperometric sensor for fast determination of hydralazine in pharmaceutical formulations. The new electrode material was characterized by X-ray diffraction (XRD), thermal analysis (TG-DTA), transmission electron microscopy (TEM) and voltammetry, exhibiting high conductivity and enhanced activity compared to the FTO electrode without modification. The α-Ni0.98Pt0.02(OH)2 electrode associated with batch injection analysis (BIA) showed good amperometric response to hydralazine, attaining detection and quantification limits of 5.93 × 10−6 and 2.0 × 10−5 mol/L, respectively, besides elevated analytical frequency (240 samples/h). The amount of hydralazine in real pharmaceutical samples were analyzed by BIA/amperometry and UV–Vis spectrophotometry, the method recommended by the United States Pharmacopeia, giving comparable results. In fact, both methods presented very good concordance (difference of 0.8%) indicating that the BIA method associated with the features of α-Ni0.98Pt0.02(OH)2 electrode is thus well-suited for electroanalytical purposes, and can be employed for determination of hydralazine in pharmaceuticals. [Display omitted]