Metal-organic framework (ZIF-67) interwoven multiwalled carbon nanotubes as a sensing platform for rapid administration of serotonin

• Published in: Journal of the Taiwan Institute of Chemical Engineers 2021-12, Vol.129, p.299-310
• Main Authors: Nataraj, Nandini, Chen, Tse-Wei, Chen, Shen Ming, Tseng, Tien-Wen, Bian, Yongzhong, Sun, Ting-Ting, Jiang, Jianzhuang
• Format: Article
• Language: English
• Subjects: Co-ZIF-67; Human blood serum; Human urine; Metal-organic framework; Neurotransmitter
• ISSN: 1876-1070; 1876-1089
• DOI: 10.1016/j.jtice.2021.09.034

•Development of an efficient electrochemical sensor for the neurotransmitter-serotonin, detection.•Lower detection limit with superior electro-oxidation was observed utilizing amperometry technique.•Real time monitoring in biological samples are evaluated.•Moreover, excellent sensing analysis were recognized and recorded. Serotonin (SRT), one among the neurotransmitters, is mainly responsible for physiological functions in human body. The effect of changes and intake of SRT can influence higher impact of peoples, thus sensing such compound with more effective and simple technique will be an extreme significance. Zeolite imidazole framework among MOF was constructed with the correlation of multiwall carbon nanotubes (ZIF-67/MWCNT) as sensor material via simple co-precipitation method. The rationally designed ZIF-67/MWCNT was evaluated for physico-chemical properties analyzed with XRD, XPS and the morphological structures were identified with FESEM. Cyclic voltammetry (CV) and amperometric (IT) technique was initiated for electrochemical detection of SRT. The ZIF-67/MWCNT exhibited a dodecahedron shape and larger surface area as agreed from BET analysis. The electrochemical results obtained at the interfacial site of ZIF-67/MWCNT proved to be more competent with excellent selectivity. SRT was electrochemically detected in human blood serum and urine as real sample analysis. The linear range was 0.049 μM to 800 μM with a lower LOD-7 nM. Moreover, the attained sensitivity was 5.613 µA µM−1 cm2 with excellent repeatability and reproducible behavior. The highly conducting matrix ZIF-67/MWCNT with abundantly accessible sites and higher surface area has gained significant results towards SRT detection. Electrochemical detection of neurotransmitter in biofluids [Display omitted]