Leptin, 20years of searching for glucose homeostasis

Leptin was discovered in 1994 (20years ago). In addition to having well-characterized effects on the regulation of energy homeostasis, leptin clearly also plays a major role in metabolic homeostasis. In fact, leptin plays an important role in the regulation of glucose homeostasis independent of food...

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Bibliographic Details
Published in:Life sciences (1973) 2015-11, Vol.140, p.4-9
Main Authors: Fernández-Formoso, Gabriela, Pérez-Sieira, Sonia, González-Touceda, David, Dieguez, Carlos, Tovar, Sulay
Format: Article
Language:English
Subjects:
Counterregulation
Glucose
Insulin
Leptin
Metabolism
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Summary:Leptin was discovered in 1994 (20years ago). In addition to having well-characterized effects on the regulation of energy homeostasis, leptin clearly also plays a major role in metabolic homeostasis. In fact, leptin plays an important role in the regulation of glucose homeostasis independent of food intake and body weight. The mechanism underlying the modulation of glucose metabolism by leptin is not completely understood, although evidence indicates that the effect occurs at both the central and peripheral levels. In this review, we will focus on the role of leptin in glucose homeostasis at the central level and its role in insulin secretion and in counteracting hormones, such as glucagon, growth hormone, cortisol and catecholamines. [Display omitted]
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2015.02.008