Antinociceptive and anti-inflammatory effect of Naringenin in different nociceptive and inflammatory mice models

• Published in: Life sciences (1973) 2019-01, Vol.217, p.148-154
• Main Authors: Xue, Na, Wu, Xianwei, Wu, Li, Li, Lu, Wang, Fang
• Format: Article
• Language: English
• Subjects: Analgesics - therapeutic use; Animals; Anti-inflammatory; Anti-Inflammatory Agents - therapeutic use; Antinociceptive; Carrageenan; Cytokines - analysis; Different mice model; Edema - chemically induced; Edema - drug therapy; Flavanones - therapeutic use; Male; Mice; Naringenin; Pain - drug therapy; Phytochemical; Phytochemicals - therapeutic use
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/j.lfs.2018.11.013

Inflammation is the vital defensive response triggered by our immune system against an infection or deleterious stimuli. This response in due course affects its own biological system leading to serious diseases like arteriosclerosis, osteoporosis, pancreatitis, cancer etc. Currently, researchers focused on utilizing phytochemicals as anti-inflammatory drugs since the drugs presently available in the market causes serious side effects and are less potent. Flavonoids are polyphenols which imparts colours to the plants and fruits. These flavonoids serve as phytonutrients to plants and they also possess antioxidant, anti-inflammatory and anti-cancer properties. Naringenin is one such flavonoid classified under flavones groups present in citrus fruits and vegetables. The present study is aimed to identify and confirm the antinociceptive and anti-inflammatory efficacy of Naringenin in different mice models. The antinociceptive effect of Naringenin was analyzed by both thermal induced and chemical induced nociceptive mice models. Carrageenan-induced paw edema test was performed to detect the anti-inflammatory effect of Naringenin and it is confirmed by analyzing the leukocyte infiltration in peritoneal cavity. Air pouch model test is performed to estimate the inhibitory property of Naringenin against proinflammatory cytokines. The potency of drug Naringenin was confirmed by treating along with opioid inhibitors naloxone and the results compared with standard drugs. To assess the muscle relaxant property of Naringenin open field test was performed. The overall results of Naringenin in different nociceptive and inflammatory mice models suggest that, Naringenin is a potent anti-inflammatory drug which relieves pain effectively and can be used in pain management therapy.