Malignant pleural mesothelioma in Turkey, 2000–2002

Both asbestos and erionite related malignant pleural mesothelioma (MPM) is a serious health problem in Turkey. Erionite has a higher potency in the lung than asbestos and familial clustering of malignant mesothelioma suggests a genetic predisposition to this cancer among affected individuals. Neithe...

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2004-08, Vol.45, p.S17-S20
Main Authors: Emri, Salih, Demir, Ahmet U
Format: Article
Language:English
Subjects:
Asbestos
Asbestos - adverse effects
Biological and medical sciences
Environmental Exposure
Erionite
Familial clustering
Genetic Predisposition to Disease
Higher carcinogenic potency of erionite
Humans
Medical sciences
Mesothelioma - etiology
Mesothelioma - pathology
Mesothelioma - virology
Neoplasm Staging - methods
Pleural Neoplasms - etiology
Pleural Neoplasms - pathology
Pleural Neoplasms - virology
Pneumology
Prognosis
Proliferation index
Survival advantage
Tumors of the respiratory system and mediastinum
Turkey
Zeolites - adverse effects
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Summary:Both asbestos and erionite related malignant pleural mesothelioma (MPM) is a serious health problem in Turkey. Erionite has a higher potency in the lung than asbestos and familial clustering of malignant mesothelioma suggests a genetic predisposition to this cancer among affected individuals. Neither Simian virus 40 (SV40) nor human herpes virus 8 (HHV-8) are co-factors in the pathenogenesis of environmentally induced mesothelioma. A survival advantage has been demonstrated in patients with asbestos-induced mesothelioma compared with erionite-induced mesothelioma. This together with the proliferation index (PI) can be used as an independent prognostic factor for patients with malignant pleural mesothelioma. It is envisaged that the application of these prognostic approaches together with the new TNM staging system will allow investigations to be more precisely carried out and evaluated.
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2004.04.009