Chemoradiotherapy versus radiotherapy alone in elderly patients with stage III non-small cell lung cancer: a systematic review and meta-analysis

Highlights • Elderly (≥70 years) stage III NSCLC patients are often excluded from standard CRT. • Our meta-analysis shows CRT is superior to RT (HR 0.66) in patients ≥70 years. • Non-hematological toxicity does not differ between CRT and RT. • Neutropenia and thrombocytopenia are more common with CR...

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2016-09, Vol.99, p.180-185
Main Authors: Dawe, David E, Christiansen, David, Swaminath, Anand, Ellis, Peter M, Rothney, Janet, Rabbani, Rasheda, Abou-Setta, Ahmed M, Zarychanski, Ryan, Mahmud, Salaheddin M
Format: Article
Language:English
Subjects:
Age Factors
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - therapy
Chemoradiotherapy
Chemoradiotherapy - adverse effects
Chemoradiotherapy - methods
Elderly
Hematology, Oncology and Palliative Medicine
Humans
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Lung Neoplasms - therapy
Neoplasm Staging
Non-small cell lung cancer
Odds Ratio
Proportional Hazards Models
Pulmonary/Respiratory
Radiotherapy - adverse effects
Radiotherapy - methods
Systematic review
Treatment
Treatment Outcome
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Summary:Highlights • Elderly (≥70 years) stage III NSCLC patients are often excluded from standard CRT. • Our meta-analysis shows CRT is superior to RT (HR 0.66) in patients ≥70 years. • Non-hematological toxicity does not differ between CRT and RT. • Neutropenia and thrombocytopenia are more common with CRT. • CRT is a reasonable standard of care for fit stage III NSCLC patients ≥70 years old
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2016.07.016