Patient-reported outcome measures (PROMs) in the management of lung cancer: A systematic review

• Published in: Lung cancer (Amsterdam, Netherlands) Netherlands), 2017-11, Vol.113, p.140-151
• Main Authors: Bouazza, Youssef Ben, Chiairi, Ibrahim, El Kharbouchi, Ouiam, De Backer, Lesley, Vanhoutte, Greetje, Janssens, Annelies, Van Meerbeeck, Jan P.
• Format: Article
• Language: English
• Subjects: Health-related quality of life; Humans; Lung cancer; Lung Neoplasms - psychology; Lung Neoplasms - therapy; Patient Reported Outcome Measures; Patient-reported outcomes; Prognosis; Quality improvement; Quality of Life - psychology; Questionnaires; Reproducibility of Results; Risk Assessment - methods; Risk Factors; Self Report
• ISSN: 0169-5002; 1872-8332
• DOI: 10.1016/j.lungcan.2017.09.011

•PROMs are indicators of the impact of the disease and treatment on health.•The EORTC QLQ-C30 and additional module QLQ-LC13 is used most frequently in lung cancer research.•The routine use of PROMs in lung cancer is still not widely recognized despite the positive effects.•PROMs appear to be a strong predictive factor of survival in lung cancer.•Electronic administration keeps developing to facilitate the process of implementation. Lung cancer is often associated with a poor quality of life, as reflected by patient-reported outcome measures (PROMs). The aim of this paper is to describe and compare the PROMs that are available. In this manuscript, we review the impact of PROMs on the management of lung cancer. Quality of the study and risk of bias were assessed using the appraisal tools recommended by the Dutch Cochrane Center. Out of 51 studies included in this review, ten instruments were identified and categorized as either generic, cancer- or lung cancer-specific. PROMs are primarily applied in scientific research to compare the therapy outcomes and in drug development to support labeling claims. The interest for the routine use of PROMs in daily practice is growing, which has positive effects on the communication with the patient, mutual decision making and the monitoring and managing of the patient. Besides that, PROMs have an independent prognostic value for survival in lung cancer and economic evaluations can be conducted using their results. Electronic platforms simplify the implementation of PROMs in the daily clinic. The EORTC QLQ-C30 and its lung cancer-specific module QLQ-LC13 are the most frequently used instruments in lung cancer patients. PROMs have the potential to improve the quality of care with a proper implementation in the routine practice. PROMS are needed to value and understand the experience of the patient.