Fabrication and characterization of electrospun membranes with highly lipoprotein repellent properties

• Published in: Materials chemistry and physics 2022-08, Vol.287, p.126281, Article 126281
• Main Authors: Rivera-Rivera, L.M., Moreno-Bárcenas, A., Hernández-Navarro, N., Ornelas-Soto, N.E., Hoyos-Palacio, L.M., Hernández-Rangel, A., Garcia-Garcia, A.
• Format: Article
• Language: English
• Subjects: Doped graphene oxide; Electrospun coating; Functional material; Lipophobic surface; Low dimensional material
• ISSN: 0254-0584; 1879-3312
• DOI: 10.1016/j.matchemphys.2022.126281

The present work presents an alternative for synthesizing low-density lipoprotein repellent membranes by the electrospinning technique. The membranes were fabricated with phosphorylcholine plus butyl methacrylate (PMB) and reinforced with nitrogen-doped graphene oxide functionalized with cysteamine (rGON-cis). The PMB concentration effects, the amount of the functionalizing agent, and the electrospinning parameters (polymer outflow and applied voltage) were studied. The maximum fiber length, average fiber diameter, diameter uniformity, and fiber quality were evaluated. The PMB membranes reinforced with rGON-cis showed an increase in the repulsion of low-density lipoproteins in function to oxidation degree. The repulsion of the membrane towards the low-density lipoproteins with medium oxidation was 26% ± 4. In contrast, the low-density lipoproteins with high oxidation increased the repulsion by 33% concerning the polymer without reinforcement. [Display omitted] •Nitrogen-doped reduced graphene oxide improves the repellent behavior front to low-density lipoproteins.•Electrospinning technique can produce bimodal fiber diameters in membranes simulating native tissues.•Functionalized Nitrogen-doped reduced graphene oxide increases the mechanical properties of PMB as stent coating.•Coatings with doped graphene oxide avoid the low-density lipoproteins incrustation in the endothelial walls.