Magnetic carboxymethyl cellulose/silk fibroin hydrogel embedded with halloysite nanotubes as a biocompatible nanobiocomposite with hyperthermia application

A novel and high potent magnetic nanobiocomposite was prepared based on Carboxymethyl cellulose (CMC) and epichlorohydrin (ECH) cross-linker interactions to form a three-dimensional cross-linked CMC hydrogel followed by silk fibroin (SF) and halloysite nanotubes (HNTs) modifications and further in s...

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Published in:Materials chemistry and physics 2022-08, Vol.287, p.126347, Article 126347
Main Authors: Eivazzadeh-Keihan, Reza, Choopani, Leila, Aghamirza Moghim Aliabadi, Hooman, Ganjali, Fatemeh, Kashtiaray, Amir, Maleki, Ali, Ahangari Cohan, Reza, Salimi Bani, Milad, Komijani, Samira, Ahadian, Mohammad Mahdi, Salehpour, Nabi, Mahdavi, Mohammad
Format: Article
Language:English
Subjects:
Carboxymethyl cellulose
Halloysite nanotubes
Hyperthermia
Magnetic nanoparticles
Silk fibroin
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Summary:A novel and high potent magnetic nanobiocomposite was prepared based on Carboxymethyl cellulose (CMC) and epichlorohydrin (ECH) cross-linker interactions to form a three-dimensional cross-linked CMC hydrogel followed by silk fibroin (SF) and halloysite nanotubes (HNTs) modifications and further in situ Fe3O4 magnetic nanoparticles (MNPs) formation. Different analytical techniques like FT-IR, EDX, FE-SEM, XRD, TGA, and VSM were used to characterize the structure of the prepared nanobiocomposite. The spherical morphology of Fe3O4 MNPs and tubular HNTs were presented in the FE-SEM images. In biological tests, since the hemolysis percent was even less than the negative control, the CMC hydrogel/SF/HNTs/Fe3O4 nanobiocomposite was fully hemocompatible. This nanobiocomposite was non-toxic toward HEK293T normal cell line. In addition, the proliferation rate and viability percentage reduction of BT549 cancer cells confirmed the anticancer property of the nanobiocomposite against breast cancer cell lines. This magnetic nanocomposite was applied in hyperthermia cancer therapy, and the maximum specific absorption rate (SAR, 67 W/g) was obtained at the concentration of 1 mg/mL under the magnetic frequency of 400 kHz. [Display omitted] •Synthesis of a magnetic nanobiocomposite based on cellulose/silk fibroin hydrogel.•This nanobiocomposite was embedded with halloysite nanotubes.•Inhibitory property against breast cancer cells resulted by this nanobiocomposite.•This nanobiocomposite has Low toxicity and hemolysis effect.•Specific absorption rate (SAR) was measured to be 67 W/g in hyperthermia tests.
ISSN:0254-0584
1879-3312
DOI:10.1016/j.matchemphys.2022.126347