Simultaneous determination of amitriptyline and venlafaxine using a novel voltammetric sensor of carbon paste electrode modified with octahedral Pd2+-doped Co3O4 composite

• Published in: Materials chemistry and physics 2023-02, Vol.296, p.127176, Article 127176
• Main Authors: Ghasemi, Leila, Jahani, Shohreh, Ghazizadeh, Mahdiyeh, Foroughi, Mohammad Mehdi
• Format: Article
• Language: English
• Subjects: Amitriptyline; Cobaltite composite; Modified electrode; Palladium; Venlafaxine
• ISSN: 0254-0584; 1879-3312
• DOI: 10.1016/j.matchemphys.2022.127176

We modified the surface of carbon paste electrode (CPE) with octahedral palladium (Pd2+)-doped cobaltite (Co3O4) composite (Oh-Pd2+:Co3O4–C/CPE) as a novel voltammetric sensor to simultaneously detect amitriptyline and venlafaxine. The techniques of differential pulse voltammetry, electrochemical impedance spectroscopy, chronoamperometry and cyclic voltammetry were employed to determine the electrochemical responses of these analytes. The findings highlighted the ability of as-fabricated sensor to facilitate the amitriptyline and venlafaxine oxidation. Peak currents for both analytes differed linearly with their concentrations (between 1.0 × 10−8 M to 9.0 × 10−4 M) for the analytical performance of the sensor. The limit of detection calculated by differential pulse voltammetry was 2.31 nM for amitriptyline and 3.56 nM for venlafaxine. We found several advantages for the modified electrode, including a simple preparation method, impressive sensitivity, admirable repeatability, and narrow detection limitations. The proposed sensor was able to detect amitriptyline and venlafaxine in real drug, serum and urine specimens. •Octahedral palladium-doped cobaltite composite were characterized by EDX, XRD and SEM.•Oh-Pd2+:Co3O4–C was used for modified carbon paste electrode.•This modified electrode was used for the simultaneous determination of amitriptyline and venlafaxine.•Modification improved the sensitivity and detection limit of the method.