Tailoring mechanical and in-vitro cytotoxicity behavior of LZ4X(X=0,1,2&3) magnesium alloy for bone implant application

• Published in: Materials chemistry and physics 2023-10, Vol.308, p.128204, Article 128204
• Main Authors: Ulaganathan, Krishnaveni, Sinnaeruvadi, Kumaran
• Format: Article
• Language: English
• Subjects: Bio-corrosion; Bio-mineralization; Hydroxyapatite compound (HAp); Mg-4Li-XZn alloy; Simulated body fluid (SBF); Thermo-mechanical process
• ISSN: 0254-0584; 1879-3312
• DOI: 10.1016/j.matchemphys.2023.128204

This present research is focused on understanding the mechanical and bio-corrosion behavior of thermo-mechanically processed i.e. rolled Mg–4Li-XZn alloys with a 90% reduction in thickness. A single-phase Mg–4Li alloy was rolled with a 90% reduction in thickness, reducing the grain size to30 μm, incorporating varying amounts of zinc. Zinc addition and thermo-mechanical processing (hot rolling) at 300 °C refine the grains and increase tensile strength, resulting in LZ43 Mg alloy with an ultimate tensile strength (UTS) of 277 ± 8 MPa and an elongation (El) of 14 ± 3%. Kokubo's simulated body fluid (SBF) was used to perform bio-corrosion and electrochemical tests (PDP and PEIS). SEM, XRD, and FTIR were used to characterize corrosion morphology and bio-mineralization products like hydroxyapatite (HAp) compound. The in-invo corrosion conduction in HEK-293 (Human embryonic kidney cell line) proves that cells were less toxic and 95% of cells remained healthy when cultured in LZ43-HR90 Mg alloy condition. [Display omitted] •The protective hydroxyapatite(HAp) had tailored the corrosion behaviour of LZ4X Mg alloy during bio-immersion test.•Twins is the region of high energy increases the affinity of ions significant to forms more hydroxyapatite compound.•SEM and FTIR confirms the presence of hydroxyapatite and magnesium hydroxide biodegradable layer formation.•Increased zinc addition during immersion test in SBF form bio-film which can dissolve in human bio-systems without any toxic effect.•The PDP & PEIS shown reduced corrosion rate with zinc addition and confirms the significant results of compound formation.