Radiation synthesis and characterization of pH-Responsive sodium Alginate/Poly(acrylic acid) nanogel loaded with ferulic acid for anticancer drug delivery

• Published in: Materials chemistry and physics 2024-08, Vol.322, p.129564, Article 129564
• Main Authors: El-Adl, Khaled, Ghobashy, Mohamed M., Ismail, Amel F.M., El-morsy, Ahmed, Shoman, Nabil A.
• Format: Article
• Language: English
• Subjects: Anticancer agent; Ferulic acid; Gamma radiation; Molecular docking; Nanogel
• ISSN: 0254-0584; 1879-3312
• DOI: 10.1016/j.matchemphys.2024.129564

This study focuses on the synthesis and characterization of a pH-responsive nanogel system composed of sodium alginate (NaAlg) and poly(acrylic acid) loaded with ferulic acid. The mechanism of nanogel formation by gamma irradiation was elucidated, highlighting the role of polymer interactions and crosslinking agents. The pHdependent release of ferulic acid from the nanogel carrier was investigated, revealing a controlled release behavior in response to pH variations. The zeta potential values remained slightly negative across the pH range, indicating the presence of surface functional groups. Transmission electron microscopy confirmed the nanogel's formation and uniform particle size at pH 1. This nanogel was considered for controlled drug delivery applications, exhibiting high physical and chemical stability of ferulic acid. Our nanogel compound 5 decreased IC50 against HepG2, A549, MCF-7 and HCT-116 by 58.22 %, 78.35 %, 45.81 %, and 47.94 % respectively. Additionally, it decreased IC50 against VEGFR2 and EGFRT790 M by 41.94 %, and 70.59 % respectively. [Display omitted] •This study described the synthesis and characterization of nanogel loaded with ferulic acid, as controlled drug delivery.•Anti-Proliferative activity of ferulic acid (4) and its nanogel (5) was examined against HepG2, A549, MCF-7 and HCT-116.•In vitro VEGFR-2 and EGFRT790M kinase assays were carried out ferulic acid and its nanogel.•Insilico Molecular docking and ADMET studies were carried out for them also.