Fabrication and in vitro biological properties of hydroxyapatite-sodium potassium niobate-barium titanate piezoelectric bioceramics

• Published in: Materials chemistry and physics 2025-01, Vol.329, p.130060, Article 130060
• Main Authors: Kaboosi, Majid, Nikzad, Leila, Mobasherpour, Iman, Ghaffari, S. Amir
• Format: Article
• Language: English
• Subjects: Antibacterial; Barium titanate; Biocompatibility; Hydroxyapatite; Piezoelectric; Sodium potassium niobate
• ISSN: 0254-0584
• DOI: 10.1016/j.matchemphys.2024.130060

The utilization of piezoelectric materials in bone implants is appealing due to the inherent piezoelectric property of natural bone. The intrinsic electrical characteristics of piezoelectric biomaterials enhance antibacterial activities, biocompatibility, and bioactivity properties. This study delves into investigating the antibacterial properties, biocompatibility, and bioactivity of three-component biocomposites: sodium potassium niobate (KNN)-barium titanate (BT)-hydroxyapatite (HA). The combination of sodium potassium niobate and barium titanate, possessing suitable piezoelectric properties, with hydroxyapatite, known for its favorable biological properties, enhances the requisite properties for a bone implant. Among the various compositions studied, the combination comprising 70 wt% of the piezoelectric component (KNN-BT) and 30 wt% hydroxyapatite, labeled as 30HKB, emerged as the most optimal blend in terms of density, morphotropic phase boundary, and other biological tests conducted. Following polarization, the antibacterial efficacy of 30HKB against S. aureus bacteria cells increased by 61 %. Furthermore, the growth and adhesion of MC3T3-E1 osteoblast cells suggest enhanced biocompatibility of the 30HKB composite attributed to surface polarization. The surface charges generated by polarization facilitated the absorption of Ca2+ ions, as well as the interaction of HPO4 - and OH- ions with the precipitated Ca2+ ions, leading to the formation of the CaP layer. Hence, polarized piezoelectric ceramics exhibit heightened bioactivity compared to their non-polarized counterparts. •Incorporating KNN-BT as a secondary phase to HA enhance the multifunctional characteristics of HA.•HA- 70 wt% KNN-BT composite had the most favorable properties in terms of density and the morphotropic phase boundary.•There are close relationship between the biological properties and the surface charges of piezoceramics.•Polarization of the HA-KNN-BT composites caused to superior antibacterial and biocompatibility effects.