Synthesis and antibacterial property of zinc loaded hydroxyapatite nanorods

• Published in: Materials letters 2012-12, Vol.89, p.233-235
• Main Authors: Chen, Xi, Tang, Qi-Li, Zhu, Ying-Jie, Zhu, Cai-Lian, Feng, Xi-Ping
• Format: Article
• Language: English
• Subjects: Antibacterial; antibacterial properties; bacteria; Biomaterials; calcium chloride; Calcium phosphate; ethanol; Fusobacterium nucleatum; Hydroxyapatite; ions; mouth; nanocarriers; Nanocomposite; nanoparticles; nanorods; Streptococcus mutans; Zinc; zinc acetate
• ISSN: 0167-577X; 1873-4979
• DOI: 10.1016/j.matlet.2012.08.115

In this work, hydroxyapatite (HAP) nanorods and amorphous calcium phosphate (ACP) nanoparticles have been prepared using CaCl2·2H2O and Na2HPO4·12H2O in aqueous solution and they are used as the nanocarriers for zinc loading. The “extraction” method is adopted for zinc loading, which is conducted in ethanol, the poor solvent for zinc acetate. Zinc loaded HAP nanorods and ACP nanoparticles are investigated for oral antibacterial application. The zinc loaded hydroxyapatite (Zn/HAP) nanorods has a favorable Zn2+ ion release property. While for zinc loaded ACP (Zn/ACP) nanoparticles, the Zn2+ ions can hardly be released. Antibacterial experiments show that Zn/HAP nanorods has the best performance to inhibit oral cavity bacteria Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum and Streptococcus mutans. The present method provides a new perspective to the preparation of antibacterial nanomaterials for oral care application. ► Zinc loaded hydroxyapatite (Zn/HAP) nanorods have been prepared. ► Zn/HAP nanorods have a favorable Zn2+ ion release property. ► Zn/HAP nanorods have a good performance to inhibit oral cavity bacteria.