Synthesis and characterization of a novel mesoporous bioactive glass/hydroxyapatite nanocomposite

A novel mesoporous bioactive glass/hydroxyapatite (MBG–HA) nanocomposite was fabricated via hydrothermal synthesis under glucose-assisted conditions using P123 as a mesoporous template. Glucose was used to create hydrophilic carbon spheres, which enriched calcium ions to form HA nanoparticles around...

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Bibliographic Details
Published in:Materials letters 2013-02, Vol.92, p.444-447
Main Authors: Liu, Tao, Lai, Dongzhi, Feng, Xinxing, Zhu, Hailin, Chen, Jianyong
Format: Article
Language:English
Subjects:
bioactive properties
biocompatibility
Biomaterials
calcium
carbon
glass
glucose
Hydroxyapatite
ions
Mesoporous bioactive glasses
Nanocomposites
Nanoparticles
texture
tissue engineering
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Summary:A novel mesoporous bioactive glass/hydroxyapatite (MBG–HA) nanocomposite was fabricated via hydrothermal synthesis under glucose-assisted conditions using P123 as a mesoporous template. Glucose was used to create hydrophilic carbon spheres, which enriched calcium ions to form HA nanoparticles around the surface. The texture properties of the MBG–HA nanocomposite were determined through a series of characterization techniques. Compared with MBG, HA nanoparticles were distributed around the mesostructure of the MBG–HA matrix. In vitro bioactive assays showed a faster apatite-like phase formation on the surface of the MBG–HA nanocomposite than that on the surface of the MBG. The novel nanocomposite with enhanced biocompatibility can potentially be used as a biomaterial for bone tissue engineering. [Display omitted] ► A novel nanocomposite mesoporous bioactive glass with HA nanoparticles was fabricated via the hydrothermal method. ► The as-prepared nanocomposite, with a pore size of 5.1nm, contained nanocrystalline HA particles in the MBG matrix. ► The nanocomposite with an enhanced biocompatibility showed good in vitro bioactivity and can serve as a new biomaterial for bone tissue regeneration.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2012.10.084