Facile development of a hollow composite microsphere with porous surface for cell delivery

Hollow polymer microspheres have attracted great attention in tissue regeneration as cell carrier. In this study, hollow poly(lactic-co-glycolic acid)/hydroxyapatite/calcium carbonate (PLGA/HA/CC) microspheres with porous surface were successfully fabricated using bioactive minerals as in situ pore-...

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Bibliographic Details
Published in:Materials letters 2013-11, Vol.111, p.238-241
Main Authors: Cheng, Delin, Gao, Huichang, Hao, Lijing, Cao, Xiaodong, Wang, Yingjun
Format: Article
Language:English
Subjects:
bioactive properties
calcium carbonate
Cell delivery
Composite materials
Macropores
Microstructure
minerals
polymers
stem cells
swine
tissue repair
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Summary:Hollow polymer microspheres have attracted great attention in tissue regeneration as cell carrier. In this study, hollow poly(lactic-co-glycolic acid)/hydroxyapatite/calcium carbonate (PLGA/HA/CC) microspheres with porous surface were successfully fabricated using bioactive minerals as in situ pore-forming agents. No templates were introduced in this facile approach. The capability of HA to hold water contributed to the formation of the porous surface and the hollow structure. Furthermore, the gas-releasing effect originating from CC decomposition facilitated the generation of opened superficial macropores. Porcine mesenchymal stem cells (PMSCs) were cultured on the microspheres and the results highlighted a better proliferation on microspheres with opened macropores. Therefore, this subtly designed microsphere shows a potential application in cell delivery. [Display omitted] •Prepare a hollow polymer microsphere with no use of conventional template.•Use bioactive minerals as in situ pore-forming agent to obtain composite but hollow microsphere.•The microsphere has a porous surface beneficial for cell delivery.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2013.08.111