Biomimetic fabrication and biocompatibility of hydroxyapatite/chitosan nanohybrid coatings on porous carbon fiber felts

Hydroxyapatite (HA)/chitosan nanohybrid coatings (HA/CS/CFs) on porous carbon fiber felts (PCFFs) have been fabricated according to the following stages: (i) deposition of chitosan/calcium phasphate precursors on PCFFs by dip-coating method and (ii) in situ formation of HA/CS/CFs by biomimetic metho...

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Bibliographic Details
Published in:Materials letters 2014-08, Vol.128, p.31-34
Main Authors: Liu, Yu-Tai, Long, Teng, Tang, Sha, Sun, Jin-Liang, Zhu, Zhen-An, Guo, Ya-Ping
Format: Article
Language:English
Subjects:
Bioceramics
Biomaterials
Carbon materials
Nanocomposites
Porous materials
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Summary:Hydroxyapatite (HA)/chitosan nanohybrid coatings (HA/CS/CFs) on porous carbon fiber felts (PCFFs) have been fabricated according to the following stages: (i) deposition of chitosan/calcium phasphate precursors on PCFFs by dip-coating method and (ii) in situ formation of HA/CS/CFs by biomimetic method. PCFFs are covered uniformly with HA nanorods and chitosan, and the macropores in PCFFs still remained. Interestingly, the calcium-deficient HA nanorods with a diameter of ~20nm and length of 50–100nm possess poor crystallinity. HA/CS/CFs exhibit the excellent in vitro biocompatibility, which can improve adhesion, spreading, and proliferation of human bone marrow stromal cells (hBMSCs). Hence, HA/CS/CFs have great potential for bone scaffold materials. [Display omitted] •Hydroxyapatite/chitosan nanohybrid coatings deposit on porous carbon fiber felts.•Calcium-deficient apatite nanorods are dispersed among chitosan.•Hydroxyapatite/chitosan nanohydrid coatings are formed via biomineralization process.•The nanohydrid coatings exhibit excellent biocompatibility.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2014.04.117