Fabrication, characterization, and antifungal activity of sodium hyaluronate-TiO2 bionanocomposite against Aspergillus niger

•TiO2 nanoparticles were synthesized via sol-gel method.•Sodium hyaluronate biopolymer was produced by Streptococcus zooepidemicus bacteria.•Sodium hyaluronate-TiO2 bionanocomposite were synthesized via in situ method.•Desirable interaction was observed between sodium hyaluronate and TiO2.•Higher an...

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Bibliographic Details
Published in:Materials letters 2017-11, Vol.207, p.113-116
Main Authors: Safaei, Mohsen, Taran, Mojtaba
Format: Article
Language:English
Subjects:
Antimicrobial resistance
Biomaterials
Polymeric composites
Sodium hyaluronate biopolymer
TiO2 nanoparticles
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Summary:•TiO2 nanoparticles were synthesized via sol-gel method.•Sodium hyaluronate biopolymer was produced by Streptococcus zooepidemicus bacteria.•Sodium hyaluronate-TiO2 bionanocomposite were synthesized via in situ method.•Desirable interaction was observed between sodium hyaluronate and TiO2.•Higher antifungal property for SH-TiO2 was observed compared to its components. In this study, characterization and antifungal properties of novel sodium hyaluronate-TiO2 bionanocomposite were studied. Sodium hyaluronate (SH) biopolymer was synthesized by bacterial fermentation, while TiO2 nanoparticles and SH-TiO2 nanocomposites were synthesized using the sol-gel and in-situ methods, respectively. The characterizations of products were surveyed by ultraviolet–visible spectroscopy (UV–vis), X-ray powder diffraction (XRD), transmission electron microscopy (TEM), and energy dispersive X-ray spectroscopy (EDS). Appling these techniques, we identified some differences in the nanocomposite structure and its components that confirmed the formation of the SH-TiO2 nanocomposite. SH-TiO2 nanocomposites showed better antifungal activity against Aspergillus niger compared to sodium hyaluronate biopolymer and TiO2 nanoparticles. The improved antifungal activity of the SH-TiO2 bionanocomposite may be elucidated by a synergistic antifungal effect.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2017.07.038