Gelatin stabilized silver nanoparticles for wound healing applications

•Gelatin stabilized silver nanoparticles were developed.•Lactose crosslinked gelatin-silver nanocomposite (LGAg) hydrogels are prepared by Schiff base bonding.•The LGAg hydrogels showed good antibacterial activity against E. coli and S. aureus.•LGAg nanocomposite hydrogels have potential use as woun...

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Bibliographic Details
Published in:Materials letters 2022-10, Vol.325, p.132851, Article 132851
Main Authors: Sudhakar, Kuncham, Won, So Yeon, Han, Sung Soo
Format: Article
Language:English
Subjects:
Antibacterial
Gelatin
Lactose
Schiff base
Silver nanoparticles
Wound dressing
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Summary:•Gelatin stabilized silver nanoparticles were developed.•Lactose crosslinked gelatin-silver nanocomposite (LGAg) hydrogels are prepared by Schiff base bonding.•The LGAg hydrogels showed good antibacterial activity against E. coli and S. aureus.•LGAg nanocomposite hydrogels have potential use as wound dressings. A simple one-step method was used to prepare lactose crosslinked gelatin-silver nanocomposite (LGAg) hydrogels by Schiff base bonding for wound dressing applications. The developed LGAg nanocomposite hydrogels were characterized by FTIR, XRD, UV-spectroscopy, and SEM to confirm hydrogel structure, morphology, and silver nanoparticle formation, and displayed potent antibacterial activities against Escherichia coli and staphylococcus aureus. Our results show the hydrogel nanocomposites produced have potential applications as wound dressing materials.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2022.132851