Hennotannic acid stabilised collagen bio-matrix for aberrant wound healing applications

•Multifunctional collagen bio matrix cross-linked with redox modulatory bio actives.•Redox modulating biomatrix for aberrant cancer wounds.•Selective killing of remnant cancer cells at tumour surgical sites. The present study demonstrates the fabrication of Lawsone cross-linked collagen bio-scaffold...

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Bibliographic Details
Published in:Materials letters 2023-05, Vol.338, p.134032, Article 134032
Main Authors: Singh, Fathe, Vijayan, Vinu, Sreekumar, Sreelekshmi, Kiran, Manikantan Syamala
Format: Article
Language:English
Subjects:
Aberrant
Biomaterial
Cancer
Lawsone
Wound
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Summary:•Multifunctional collagen bio matrix cross-linked with redox modulatory bio actives.•Redox modulating biomatrix for aberrant cancer wounds.•Selective killing of remnant cancer cells at tumour surgical sites. The present study demonstrates the fabrication of Lawsone cross-linked collagen bio-scaffold for management of aberrant wound healing especially wound healing in post-surgical cancer margins. Lawsone reinforced with collagen resulted in increased thermal and mechanical stability, structural integrity, decreased proteolytic susceptibility and biocompatibility. It exhibited anti-angiogenic, anti-migratory and apoptotic effect selectively in cancer cells mediated by intrinsic increase of reactive oxygen species production in cancer cells. The biological properties exhibited by Lawsone cross-linked collagen bio-scaffold makes it a promising anti-cancerous wound dressing 3-D bio-matrix biomaterial for healing of postsurgical wound margins.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2023.134032