Polymeric biocide-modified zinc oxide@alginate nanocomposites for drug delivery and antibacterial applications

A polymeric biocide polyhexamethylene guanidine (PHMG) modified alginate-coated zinc oxide nanocomposite (ZnO@Alg-PHMG) has been proposed for drug delivery and antibacterial applications. A range of instrumental characterizations including FT-IR, XRD, SEM, TGA, and zeta potential were utilized to ve...

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Bibliographic Details
Published in:Materials letters 2024-10, Vol.372, p.136938, Article 136938
Main Authors: Mohan, Anandhu, Santhamoorthy, Madhappan, Ashwini, Munusamy, Saravana Mani, Kailasam, Ramkumar, Vanaraj, Lin, Mei-Ching, Kim, Seong-Cheol, Kumarasamy, Keerthika, Phan, Thi Tuong Vy
Format: Article
Language:English
Subjects:
Antibacterial activity
Drug delivery
PHMG
Polymeric biocide
ZnO nanoparticles
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Summary:A polymeric biocide polyhexamethylene guanidine (PHMG) modified alginate-coated zinc oxide nanocomposite (ZnO@Alg-PHMG) has been proposed for drug delivery and antibacterial applications. A range of instrumental characterizations including FT-IR, XRD, SEM, TGA, and zeta potential were utilized to verify the ZnO@Alg-PHMG synthesis. The drug delivery behavior of the ZnO@Alg-PHMG was determined using curcumin (Cur) as a model antibacterial agent. Further, the PHMG-induced antibacterial activity of the ZnO@Alg-PHMG was evaluated against Gram-positive (Staphylococcus aureus, S. aureus) and Gram-negative (Escherichia coli, E. coli) bacterial pathogens.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2024.136938