Production of microneedle patches coated with polyvinyl-alcohol/sucrose/gentamicin sulfate for skin treatment

[Display omitted] •MN patches were printed by DLP.•MNs were coated with GEN loaded PVA/sucrose.•GEN increased the compression strength. In this study, resin-based microneedle (MN) patches were fabricated using a digital light processing (DLP) printer. The needles were coated with gentamicin sulfate...

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Bibliographic Details
Published in:Materials letters 2025-01, Vol.378, p.137557, Article 137557
Main Authors: Mutlu, Mehmet Eren, Akdag, Zekiye, Pilavci, Esra, Ulag, Songul, Daglilar, Sibel, Gunduz, Oguzhan
Format: Article
Language:English
Subjects:
3D printing
Biomaterials
Digital light processing (DLP)
Gentamicin sulfate
Microneedle
Polyvinyl alcohol (PVA)
Sucrose
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Summary:[Display omitted] •MN patches were printed by DLP.•MNs were coated with GEN loaded PVA/sucrose.•GEN increased the compression strength. In this study, resin-based microneedle (MN) patches were fabricated using a digital light processing (DLP) printer. The needles were coated with gentamicin sulfate (GEN)-loaded with 13.3 % PVA/25 % sucrose solution by immersion. The SEM results showed that the coating was homogeneous and uniformly conical. Analysing the in vitro release profiles of GEN, it was found that it was ultimately released within 312 h. The compression test results demonstrated that GEN addition increased the compression strength to the value of 2.17 ± 0.01 N/mm2.
ISSN:0167-577X
DOI:10.1016/j.matlet.2024.137557