Curcumin modified Fe3O4 with efficient SDT for the treatment of breast cancer

•The Fe3O4/Cur nanomaterial is prepared by a simple hydrothermal method.•The Fe3O4/Cur can generate large amounts of ROS at US irradiation.•The Fe3O4/Cur can kill breast cancer cells rapidly at US irradiation. Sonodynamic therapy (SDT) is a non-invasive anti-tumor strategy with good efficacy, strong...

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Bibliographic Details
Published in:Materials letters 2025-02, Vol.381, p.137721, Article 137721
Main Authors: Bai, Xueqi, Li, Shihang, Yang, Jiayang, Lu, Ying, Li, Rong, Song, Jianbo, Guo, Xiudong
Format: Article
Language:English
Subjects:
Breast cancer
Curcumin
Nanomaterial
SDT
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Summary:•The Fe3O4/Cur nanomaterial is prepared by a simple hydrothermal method.•The Fe3O4/Cur can generate large amounts of ROS at US irradiation.•The Fe3O4/Cur can kill breast cancer cells rapidly at US irradiation. Sonodynamic therapy (SDT) is a non-invasive anti-tumor strategy with good efficacy, strong penetration and few side effects. However, the microenvironment of tumor hypoxia and high expression of hydrogen peroxide (H2O2) limits the efficiency of SDT. In this work, we have prepared a ultrasound-enhanced anti-tumor material by hydrothermal method, and the nanomaterials with optimal catalytic ability are identified by controlling the quality of curcumin (Fe3O4/Cur). The Fe3O4/Cur is not only capable of generating ROS by ultrasound excitation, but also generates ROS by the Fenton reaction with H2O2, and the SDT effect of Fe3O4/Cur is further enhanced. Under ultrasound stimulation, the Fe3O4/Cur can effectively kill the breast cancer cells within 15 min. This work provides a new idea for the treatment of breast cancer.
ISSN:0167-577X
DOI:10.1016/j.matlet.2024.137721