Magnetite Nanoparticles Functionalized with Vitamin E Analogues: Anticancer Effects

Magnetite nanoparticles functionalized with alpha-tocopheryl succinate (Nps@α-TOS) increase anticancer activity of this vitamin E analogue. Previously, we reported Nps@α-TOS protect and enhance bioactivity of α-TOS in vitro. Nps@α-TOS selectively affected cervical cancer cells, without toxic effects...

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Main Authors: Angulo-Molina, A., Méndez-Rojas, M.A., Palacios-Hernández, T., Contreras-López, O.E., Hirata-Flores, G.A., Flores, J.C., Flores, K.L., Velázquez, C., Robles-Zepeda, R., Silva-Campa, E., Sarabia, A., Barboza-Flores, M., Pedroza-Montero, M., Reyes-Leyva, J.R., Hernández, J.
Format: Conference Proceeding
Language:English
Subjects:
cancer
magnetite nanoparticles
vitamin E analogue
α-tocopheril succinate
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Summary:Magnetite nanoparticles functionalized with alpha-tocopheryl succinate (Nps@α-TOS) increase anticancer activity of this vitamin E analogue. Previously, we reported Nps@α-TOS protect and enhance bioactivity of α-TOS in vitro. Nps@α-TOS selectively affected cervical cancer cells, without toxic effects for normal cells. The nanoparticles were internalized and accumulated around the nucleus. Severe morphological cell changes and lost viability were observed at 72h post-treatment in contrast with non-effect in normal fibroblasts cells. These results suggested a cytotoxic effect in cancer cells and biocompatibility in normal cells. Further studies are needed in order to evaluate synergic anticancer bioactivity of Nps@α-TOS with other alternative treatments.
ISSN:2214-7853
2214-7853
DOI:10.1016/j.matpr.2016.01.116