Nanofibrous scaffolds from chitosan and poly(caprolactone) for excision wound healing application in canine model

Poly (caprolactone)-Chitosan- Poly(vinyl alcohol) (PCL: Cs: PVA) nanofibrous blend scaffolds were fabricated in an optimum mass ratio of 2:1:1.5 using electrospinning technique. In this study the scaffolds were examined in excisional cutting wounds healing on dorsum skin of canine models (n=5). Macr...

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Bibliographic Details
Main Authors: Gholipour-Kanani, Adeleh, Samadikuchaksaraei, Ali, Mohsenzadegan, Monire, Fayyazi, Mohahmadreza
Format: Conference Proceeding
Language:English
Subjects:
Chitosan
Nanofibrous scaffolds
PCL
Wound healing
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Summary:Poly (caprolactone)-Chitosan- Poly(vinyl alcohol) (PCL: Cs: PVA) nanofibrous blend scaffolds were fabricated in an optimum mass ratio of 2:1:1.5 using electrospinning technique. In this study the scaffolds were examined in excisional cutting wounds healing on dorsum skin of canine models (n=5). Macroscopic results showed good aspect healing effect of scaffolds in compared with control wounds especially after 21 days post operating. Pathological studies showed that the healing rate was more rapid (about 50% faster) in the test group compare to control ones. Overall, the results indicated that the produced nanofibrous scaffold could be considered as promising materials for wounds healing.
ISSN:2214-7853
2214-7853
DOI:10.1016/j.matpr.2018.04.172