An investigation on host-guest complexation of Metformin hydrochloride with hydroxypropyl-α-cyclodextrin for enhanced oral bioavailability

Metformin hydrochloride is an orally administered biguanide which is an oral anti-hyperglycemic agent. It shows incomplete absorption from the gastrointestinal tract and the absolute bioavailability is 50–60% with relatively short plasma half-life of 1.5–4.5 h. In this study the host-guest complexat...

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Bibliographic Details
Published in:Materials today : proceedings 2020, Vol.21, p.514-518
Main Authors: Lizy Roselet, S., Prema Kumari, J.
Format: Article
Language:English
Subjects:
Anti-hyperglycemic agent
Bioavailability
Hydroxypropyl-α-cyclodextrin
Inclusion complexes
Metformin hydrochloride
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Summary:Metformin hydrochloride is an orally administered biguanide which is an oral anti-hyperglycemic agent. It shows incomplete absorption from the gastrointestinal tract and the absolute bioavailability is 50–60% with relatively short plasma half-life of 1.5–4.5 h. In this study the host-guest complexation of hydroxypropyl-α-cyclodextrin with Metformin hydrochloride is discussed. Inclusion complexes of Metformin hydrochloride with hydroxypropyl-α-cyclodextrin were prepared in solid and liquid state and they are characterized using spectrophotometry, fluorimetry, 1H NMR and phase solubility studies. The subsistence of host-guest interaction makes hydroxypropyl-α-cyclodextrin a suitable candidate for the enhancement of bioavailability of Metformin hydrochloride.
ISSN:2214-7853
2214-7853
DOI:10.1016/j.matpr.2019.06.650