Highly sensitive antimonene based SPR biosensor for miRNA detection

• Main Authors: Singh, Maneesh Kumar, Pal, Sarika, Prajapati, Y.K., Saini, J.P.
• Format: Conference Proceeding
• Language: English
• Subjects: Antimonene; Cancer biomarker; miRNA; Sensitivity; SPR biosensor
• ISSN: 2214-7853; 2214-7853
• DOI: 10.1016/j.matpr.2020.05.183

Here, we proposed and investigated theoretically, the performance of an antimonene based SPR biosensor (Structure: BK-7 prism/Au/Antimonene/Sensing layer). The proposed SPR can be used to detect dysregulated miRNA for timely diagnosis of tumour or cancer like deadly disease. The miRNA are an ideal biomarker for timely detection and diagnosis of life threatening diseases. Literature indicates that miRNAs are involved in diagnosis of nearly all kinds of diseases. Angular interrogation method based on Kretschmann geometry is used here to analyze results analytically at 633 nm operating wavelength. Highest sensitivity of 181.925°/RIU is obtained for proposed design with two layer of antimonene. The result shows that sensitivity enhancement of 14.46%, 25.94% and 6.47% for proposed SPR biosensor is obtained at monolayer, bilayer and trilayer of antimonene respectively. The sensitivity of proposed antimonene based SPR biosensor is better as compared to conventional and Au-Graphene based SPR biosensors. Finally, we checked the effect of refractive index of sensing layer on SPR biosensor's sensitivity and detection accuracy. The proposed SPR design can find its potential applications practically for early diagnosis of cancer by using available fabrication techniques for antimonene.