Pd-catalyzed oxidative homocoupling of arylboronic acids in WEPA: A sustainable access to symmetrical biaryls under added base and ligand-free ambient conditions

• Published in: Molecular catalysis 2021-02, Vol.501, p.111366, Article 111366
• Main Authors: Appa, Rama Moorthy, Lakshmidevi, Jangam, Naidu, Bandameeda Ramesh, Venkateswarlu, Katta
• Format: Article
• Language: English
• Subjects: Arylboronic acids; Oxidative homocoupling; Pd(OAc)2; Renewable basic media; Water extract of pomegranate ash
• ISSN: 2468-8231; 2468-8231
• DOI: 10.1016/j.mcat.2020.111366

A sustainable and versatile protocol has been unveiled for the Pd-catalyzed oxidative homocoupling of arylboronic acids in biorenewable, waste-derived basic media, WEPA at room temperature in open-air. [Display omitted] •External oxidant, added base and ligand free homocoupling of arylboronic acids.•Biorenewable base and reaction medium.•Utilization of waste derivatives for the CC coupling reactions.•High yielding and quick reactions. Symmetrical and unsymmetrical biaryls comprises a diverse class of biologically eloquent organic compounds. We herein report, a quick and eco-friendly protocol for the synthesis of biaryls by an oxidative (aerobic) homocoupling of arylboronic acids (ABAs) using Pd(OAc)2 in water extract of pomogranate ash (WEPA) as an efficient agro-waste(bio)-derived aqueous (basic) media. The reactions were executed at ambient aerobic conditions in the absence of external base and ligand to result symmetrical biaryls in excellent yields. The use of renewable media with an effective exploitation of waste, short reaction times, excellent yields of products, easy separation of the products, unnecessating the external base, oxidant, ligand or volatile organic solvents and ambient reaction conditions are the vital insights of the present protocol.