Enhanced HLA-DR expression on T-lymphocytes from patients in early stages of non-surgical sepsis

Early detection of sepsis is a critical step to improve patient's survival and cellular markers effective diagnosis tools. The aim of this work was to evaluate HLA-DR expression on peripheral T-lymphocytes (CD3+), a marker associate to T-cell activation, as an early sepsis detection tool. A cro...

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Bibliographic Details
Published in:Medicina clínica (English ed.) 2019-05, Vol.152 (9), p.346-349
Main Authors: Fernández-Grande, Esther, Cabrera, Carmen María, González, Blanca, Varela, Carolina, Urra, José Miguel
Format: Article
Language:English
Subjects:
HLA-DR
Linfocitos T
Sepsis
T-lymphocytes
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Summary:Early detection of sepsis is a critical step to improve patient's survival and cellular markers effective diagnosis tools. The aim of this work was to evaluate HLA-DR expression on peripheral T-lymphocytes (CD3+), a marker associate to T-cell activation, as an early sepsis detection tool. A cross-sectional study was conducted in twenty-six patients with confirmed sepsis by blood culture, eighteen healthy individuals and four patients with systemic inflammatory response syndrome. The analysis of the HLA-DR expression was carried by flow cytometry. The patients with confirmed sepsis had significantly higher percentage of CD3+/HLA-DR+ lymphocytes compared with both, patients with SIRS (20.37±9.42 vs. 8.7±2.9; p
ISSN:2387-0206
2387-0206
DOI:10.1016/j.medcle.2019.02.014