Impact of cardiac 99mTc-HMDP uptake on myocardial function and left ventricular filling pressure in patients with transthyretin amyloidosis

• Published in: Médecine nucléaire : imagerie fonctionelle et métabolique 2017-05, Vol.41 (3), p.149-149
• Main Authors: Pascal, P., Pradel, S., Brun, S., Victor, G., Berry, I.
• Format: Article
• Language: English
• Subjects: 99mTc-HDP; Amylose; Cardiologie
• ISSN: 0928-1258; 1878-6820
• DOI: 10.1016/j.mednuc.2017.02.035

Pathophysiology of 99mTc-labeled phosphate agents cardiac uptake by scintigraphy in transthyretin-related (TTR) amyloidosis remains unclear. The impact of cardiac uptake on cardiac function is unknown. The aim of this study was to explore the pattern of 99mTc-labeled phosphate agents cardiac uptake by scintigraphy and its impact on left ventricular (LV) functions assessed by echocardiography. Fifty patients with TTR cardiac amyloidosis underwent 99mTc- hydroxymethylene-diphosphonate (99mTc-HMDP) scintigraphy and echocardiography with measure of LV morphology, longitudinal strain (LS), systolic and diastolic functions. Cardiac retention by scintigraphy was assessed by visual scoring and the heart/whole body (H/B) ratio was calculated by dividing counts in the heart by counts in late whole body images. The mean population age was 79±10 years. Most of the patients (88%) were male. Visual score was 2 and 3 for 6 (12%) and 44 (88%) patients, respectively. Mean H/WB ratio was 12±7. Mean LV ejection fraction and global LS were 51±10% and -10±3%, respectively. H/WB ratio was correlated with global LS (R=0.408, P=0.003), Ea (R=-0.566, P