Comparison of 68GA-FAPI-04 PET/CT and 18F-FDG PET/CT in detection of metastatic bone disease in various cancers

Our aim in this retrospective study was to compare the diagnostic accuracy of 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT in detecting bone metastases of various cancers and to evaluate the potential usefulness of 68Ga-FAPI-04 PET/CT in detecting metastatic bone disease. Our retrospective study included...

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Bibliographic Details
Published in:Médecine nucléaire : imagerie fonctionelle et métabolique 2023-08, Vol.47 (4), p.200-207
Main Authors: Kepenek, F., Kaplan, İ., Can, C., Karaoğlan, H., Güzel, Y., Kömek, H.
Format: Article
Language:English
Subjects:
18F- FDG
68Ga-FAPI-04
Bone metastasis
Métastase osseuse
PET/CT
SUVmax
TEP/TDM
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Summary:Our aim in this retrospective study was to compare the diagnostic accuracy of 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT in detecting bone metastases of various cancers and to evaluate the potential usefulness of 68Ga-FAPI-04 PET/CT in detecting metastatic bone disease. Our retrospective study included 44 patients diagnosed with bone metastases due to various cancers between January 2021 and February 2022. All patients underwent 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT imaging within 14 days. In the semi-quantitative analysis of the skeletal system, all regions with higher uptake than background activity were considered pathological. SUVmax and Metastasis-to-background ratio (TBR) values were calculated from metastatic sites. A total of 827 bone metastases were detected in our study. The diagnostic accuracies of FAPI PET/CT and 18F-FDG PET/CT were 91.8% and 81.5%, respectively (P
ISSN:0928-1258
1878-6820
DOI:10.1016/j.mednuc.2022.12.002