Whole-genome sequencing identification of a multidrug-resistant Salmonella enterica serovar Typhimurium strain carrying bla NDM-5 from Guangdong, China

A carbapenem-resistant Salmonella enterica serovar Typhimurium (sequence type 34 [ST34]) strain was isolated from a fecal specimen from a child with acute diarrhea. Whole-genome sequencing revealed that the 84.5-kb IncFII plasmid pST41-NDM carrying the NDM-5 carbapenemase gene possesses a structure...

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Bibliographic Details
Published in:Infection, genetics and evolution genetics and evolution, 2017-11, Vol.55, p.195-198
Main Authors: Li, Xiaoyan, Jiang, Yan, Wu, Kuihai, Zhou, Yong, Liu, Ruike, Cao, Yan, Wu, Aiwu, Qiu, Yurong
Format: Article
Language:English
Subjects:
beta-Lactamases - genetics
China
Computational Biology - methods
Drug Resistance, Multiple, Bacterial
Genome, Bacterial
Genomics - methods
Humans
Mutagenesis, Insertional
Plasmids - genetics
Salmonella Infections - microbiology
Salmonella typhimurium - drug effects
Salmonella typhimurium - genetics
Whole Genome Sequencing
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Summary:A carbapenem-resistant Salmonella enterica serovar Typhimurium (sequence type 34 [ST34]) strain was isolated from a fecal specimen from a child with acute diarrhea. Whole-genome sequencing revealed that the 84.5-kb IncFII plasmid pST41-NDM carrying the NDM-5 carbapenemase gene possesses a structure identical to that of the IncFII-type plasmid backbone. However, the bla flanking sequence found in this plasmid is identical to the bla -positive IncX3 plasmids carried by 10 strains of Enterobacteriaceae identified in the same hospital.
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2017.09.005