Adipose tissue transplantation may be a potential treatment for diabetes, atherosclerosis and nonalcoholic steatohepatitis

Summary Adipose tissue is critical in energy homeostasis. Adipose tissue ‘buffers’ the lipids and energy rich compounds which are pumped into the blood stream soon after meals. It senses, signals other organs like liver and brain about the energy reserves via adipokines. Adiponectin, the most abunda...

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Bibliographic Details
Published in:Medical hypotheses 2009-03, Vol.72 (3), p.247-249
Main Author: Sanal, Madhusudana Girija
Format: Article
Language:English
Subjects:
Adipose Tissue - transplantation
Alcoholism - complications
Alcoholism - surgery
Animals
Atherosclerosis - surgery
Diabetes Mellitus - surgery
Disease Models, Animal
Fatty Liver - surgery
Hepatitis - surgery
Humans
Internal Medicine
Treatment Outcome
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Summary:Summary Adipose tissue is critical in energy homeostasis. Adipose tissue ‘buffers’ the lipids and energy rich compounds which are pumped into the blood stream soon after meals. It senses, signals other organs like liver and brain about the energy reserves via adipokines. Adiponectin, the most abundant adipokine has insulin sensitizing, anti-inflammatory antiatherogenic and antisteatotic effects. Adipose tissue dysfunction is accompanied by abnormal lipid distribution and storage which contributes to diseases like diabetes, nonalcoholic fatty liver disease and atherosclerosis. Obesity and lipodystrophy are associated with dysfunctional adipocytes. Pre-adipocytes are easy to isolate and culture. A personalized depot specific liposuction to remove the inactive adipocytes followed by adipocyte repopulation could be useful in the treatment of these diseases.
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2008.10.009