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Molecular biology of autism’s etiology – An alternative mechanism

Autism is a neuropathologic condition believed to be the consequence of cerebral dysconnectivity. Hypomyelination of axons in brain nerve pathways parallels behavioral abnormalities characteristic of autism. The present discussion will examine the functional association of insulin-like growth factor...

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Published in:	Medical hypotheses 2019-09, Vol.130, p.109272, Article 109272
Main Authors:	Steinman, Gary, Mankuta, David
Format:	Article
Language:	English
Subjects:	Autism Autistic Disorder - blood Autistic Disorder - etiology Autistic Disorder - genetics Axon Axons - metabolism Biomarkers Biomarkers - metabolism Brain - physiopathology Child, Preschool Etiology Female Humans IGF1 Infant Insulin-Like Growth Factor I - genetics Magnetic Resonance Imaging Male Models, Neurological Myelin Myelin Sheath - metabolism Polymorphism, Single Nucleotide
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container_title	Medical hypotheses
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description	Autism is a neuropathologic condition believed to be the consequence of cerebral dysconnectivity. Hypomyelination of axons in brain nerve pathways parallels behavioral abnormalities characteristic of autism. The present discussion will examine the functional association of insulin-like growth factor-1 (IGF1) to neo-neuron myelination, especially in autistic children. These structural defects apparently correlate with a reduced level of circulating IGF. In addition, the potential connection of single nucleotide polymorphism to the etiology of autism is considered. Pharmaceutical and nutritional supplements that may enhance IGF1 to reduce the incidence of autism are proposed.
doi_str_mv	10.1016/j.mehy.2019.109272
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subjects	Autism Autistic Disorder - blood Autistic Disorder - etiology Autistic Disorder - genetics Axon Axons - metabolism Biomarkers Biomarkers - metabolism Brain - physiopathology Child, Preschool Etiology Female Humans IGF1 Infant Insulin-Like Growth Factor I - genetics Magnetic Resonance Imaging Male Models, Neurological Myelin Myelin Sheath - metabolism Polymorphism, Single Nucleotide
title	Molecular biology of autism’s etiology – An alternative mechanism
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