Synthesis of H (type 4) trisaccharide, key structural fragment of globo-H and fucosyl-GM1 cancer-associated antigens

[Display omitted] A convenient synthesis of Fucα1-2Galβ1-3GalNAcβ-OCH2CH2CH2NH2 (trisaccharide H type 4) is described. This glycan is the terminal part of glycosphingolipids globo-H and fucosyl-GM1 known as cancer-associated carbohydrate antigens.

Saved in:
Bibliographic Details
Published in:Mendeleev communications 2018-07, Vol.28 (4), p.421-422
Main Authors: Pazynina, Galina V., Tsygankova, Svetlana V., Ryzhov, Ivan M., Paramonov, Alexander S., Nicolai, Bovin, V.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] A convenient synthesis of Fucα1-2Galβ1-3GalNAcβ-OCH2CH2CH2NH2 (trisaccharide H type 4) is described. This glycan is the terminal part of glycosphingolipids globo-H and fucosyl-GM1 known as cancer-associated carbohydrate antigens.
ISSN:0959-9436
DOI:10.1016/j.mencom.2018.07.027