Reactions of chromone-3-carboxamides with 2-cyanothioacetamides

[Display omitted] Chromone-3-carboxamides react with cyanothioacetamide in the presence of NaOEt in boiling ethanol to form 5-oxo-2-thioxo-1,5-dihydro-2H-chromeno[4,3-b]pyridine-3-carbonitriles (67–87% yields), whereas their reaction with N-methylcyanothioacetamide and a catalytic amount of Et3N in...

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Published in:Mendeleev communications 2019-01, Vol.29 (1), p.67-68
Main Authors: Kornev, Mikhail Yu, Tishin, Denis S., Sosnovskikh, Vyacheslav Ya
Format: Article
Language:English
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Summary:[Display omitted] Chromone-3-carboxamides react with cyanothioacetamide in the presence of NaOEt in boiling ethanol to form 5-oxo-2-thioxo-1,5-dihydro-2H-chromeno[4,3-b]pyridine-3-carbonitriles (67–87% yields), whereas their reaction with N-methylcyanothioacetamide and a catalytic amount of Et3N in boiling ethanol affords 5-cyano-2-(2-hydroxyphenyl)-1-methyl-6-thioxo-1,6-dihydropyridine-3-carboxamides in 57–73% yields.
ISSN:0959-9436
DOI:10.1016/j.mencom.2019.01.022