New design of cationic alkyl glycoglycerolipids toxic to tumor cells

[Display omitted] New glycosylated alkyl glycerolipids bearing a cationic group at the C6 position of sugar moiety have been synthesized and tested as potential anticancer drugs. The compounds demonstrated cytotoxicity and selectivity against tumor cells at low micromolar concentration.

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Bibliographic Details
Published in:Mendeleev communications 2019-03, Vol.29 (2), p.166-168
Main Authors: Morozova, Nina G., Shmendel, Elena V., Timofeev, Grigory A., Ivanov, Igor V., Kubasova, Tatyana S., Plyavnik, Natalia V., Markova, Alina A., Maslov, Mikhail A., Shtil, Alexander A.
Format: Article
Language:English
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Summary:[Display omitted] New glycosylated alkyl glycerolipids bearing a cationic group at the C6 position of sugar moiety have been synthesized and tested as potential anticancer drugs. The compounds demonstrated cytotoxicity and selectivity against tumor cells at low micromolar concentration.
ISSN:0959-9436
DOI:10.1016/j.mencom.2019.03.016