Unusual stereoselectivity of methionine-γ-lyase from Citrobacterfreundii toward diastereomeric (S)-methionine S-oxide

[Display omitted] Using a diastereomeric mixture of (S)-methionine S-oxide as an example, kinetic preference of methionine-γ-lyase toward a stereogenic center at the γ-sulfur atom of the (2S, RS) diastereomer was discovered for the first time.

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Bibliographic Details
Published in:Mendeleev communications 2021-03, Vol.31 (2), p.236-238
Main Authors: Faleev, Nikolai G., Tsvetikova, Marina A., Ilyin, Mikhail M., Yufryakov, Vyacheslav S., Kolotyrkina, Natal’ya G., Kulikova, Viktoria V., Demidkina, Tatiana V., Kochetkov, Konstantin A.
Format: Article
Language:English
Subjects:
(S)-methionine S-oxide
diastereomers
kinetic resolution
methionine-γ-lyase
stereoselectivity
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Summary:[Display omitted] Using a diastereomeric mixture of (S)-methionine S-oxide as an example, kinetic preference of methionine-γ-lyase toward a stereogenic center at the γ-sulfur atom of the (2S, RS) diastereomer was discovered for the first time.
ISSN:0959-9436
DOI:10.1016/j.mencom.2021.03.030