Synthesis of spacer armed Kdn(2→6') and (2→3')-lactosamines for immunochemical research

[Display omitted] Glycosylation of lactosamine acceptors with Kdn thioglycoside donors in the presence of NIS/TfOH as a promoter affords products with both α- and β-ketosidic linkage (2–6' or 2–3') between the Kdn and Gal residues. After deprotection, the synthesized trisaccharides and gly...

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Bibliographic Details
Published in:Mendeleev communications 2021-07, Vol.31 (4), p.490-492
Main Authors: Chinarev, Alexander A., Sablina, Marina A., Kunetskiy, Roman A., Shilova, Nadezhda V., Polyakova, Svetlana V., Paramonov, Alexander S., Saha, Jaideep, Bovin, Nicolai V.
Format: Article
Language:English
Subjects:
glycochip
human serum antibodies
Kdn
sialooligosaccharides
sialylation
thiosialic donors
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Summary:[Display omitted] Glycosylation of lactosamine acceptors with Kdn thioglycoside donors in the presence of NIS/TfOH as a promoter affords products with both α- and β-ketosidic linkage (2–6' or 2–3') between the Kdn and Gal residues. After deprotection, the synthesized trisaccharides and glycans containing Neu5Ac were printed to a chip and their comparative interaction with human serum antibodies was explored.
ISSN:0959-9436
DOI:10.1016/j.mencom.2021.07.017