Urea derivatives of spirocyclic piperidines endowed with antibacterial activity

[Display omitted] Antimycobacterial activity of certain ureas as well as spirocyclic piperidines described in the literature prompted us to synthesize and test a series of hybrids of spirocyclic piperidine with ureas. Surprisingly, no activity was detected against Mycobacterium tuberculosis. However...

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Bibliographic Details
Published in:Mendeleev communications 2023-01, Vol.33 (1), p.109-111
Main Authors: Lukin, Alexei, Komarova, Kristina, Vinogradova, Lyubov, Rogacheva, Elizaveta, Kraeva, Lyudmila, Dogonadge, Marine, Vinogradova, Tatiana, Krasavin, Mikhail
Format: Article
Language:English
Subjects:
antibacterial activity
antimycobacterial activity
epoxide hydrolase
membrane transporter Mmpl3
piperidines
spirocyclic compounds
ureas
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Summary:[Display omitted] Antimycobacterial activity of certain ureas as well as spirocyclic piperidines described in the literature prompted us to synthesize and test a series of hybrids of spirocyclic piperidine with ureas. Surprisingly, no activity was detected against Mycobacterium tuberculosis. However, significant antibacterial activity was identified and confirmed against common gram-positive as well as gram-negative bacteria.
ISSN:0959-9436
DOI:10.1016/j.mencom.2023.01.034