Synthesis and optical characteristics of 4-styrylpyridinium dyes and their conjugates with antibody

[Display omitted] Two new styryl-type dyes modified with the succinimide ester group were prepared for conjugation with antibodies. The optical characteristics of the obtained compounds in different solvents were studied, and the solvatochromic properties of these dyes were revealed. The applicabili...

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Bibliographic Details
Published in:Mendeleev communications 2023-05, Vol.33 (3), p.384-386
Main Authors: Efimova, Anna S., Ustimova, Mariya A., Maksimova, Margarita A., Frolova, Anastasya Yu, Martynov, Vladimir I., Deyev, Sergey M., Pakhomov, Alexey A., Fedorov, Yurii V., Fedorova, Olga A.
Format: Article
Language:English
Subjects:
antibody
covalent labeling
fluorescent probes
protein
pyridinium salts
styryl dyes
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Summary:[Display omitted] Two new styryl-type dyes modified with the succinimide ester group were prepared for conjugation with antibodies. The optical characteristics of the obtained compounds in different solvents were studied, and the solvatochromic properties of these dyes were revealed. The applicability of the dyes as protein labels was demonstrated in cyto-fluorometry and fluorescence microscopy.
ISSN:0959-9436
DOI:10.1016/j.mencom.2023.04.027