Microwave-assisted synthesis of 5-aryl-3-hydroxy-2-oxindole derivatives and evaluation of their antiglaucomic activity

[Display omitted] A set of new 5-aryl-3-hydroxy-2-oxindoles was synthesized by decarboxylative condensation of the corresponding 5-aryl-substituted isatins with malonic or cyanoacetic acids under microwave irradiation. The antiglaucomic activity of the obtained compounds was evaluated. The most wate...

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Bibliographic Details
Published in:Mendeleev communications 2023-07, Vol.33 (4), p.550-552
Main Authors: Efremov, Alexander M., Babkov, Denis A., Beznos, Olga V., Sokolova, Elena V., Spasov, Alexander A., Ivanov, Vladimir N., Kurkin, Alexander V., Chesnokova, Natalia B., Lozinskaya, Natalia A.
Format: Article
Language:English
Subjects:
antiglaucomic
condensation
indolin-2-one
intraocular pressure
microwave irradiation
NRH:quinone oxidoreductase 2 inhibitors
oxindole
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Summary:[Display omitted] A set of new 5-aryl-3-hydroxy-2-oxindoles was synthesized by decarboxylative condensation of the corresponding 5-aryl-substituted isatins with malonic or cyanoacetic acids under microwave irradiation. The antiglaucomic activity of the obtained compounds was evaluated. The most water soluble compounds can reduce the intraocular pressure (IOP) up to 2 Torr.
ISSN:0959-9436
DOI:10.1016/j.mencom.2023.06.035