Changes of metabolic and inflammatory markers in HIV infection: glucose, lipids, serum Hs-CRP and myeloperoxidase

• Published in: Metabolism, clinical and experimental clinical and experimental, 2012-10, Vol.61 (10), p.1353-1360
• Main Authors: Borato, Danielle Cristyane Kalva, Parabocz, Gisele Chibinski, Ribas, Sônia Regina Weber, Kalva-Filho, Carlos Augusto, Borba, Luciana Maria, Ito, Carmen Antonia Sanches, Bail, Larissa, dos Santos, Fábio André, Vellosa, José Carlos Rebuglio
• Format: Article
• Language: English
• Subjects: Adult; Antiretroviral Therapy, Highly Active; Biological and medical sciences; Blood Glucose - analysis; C-Reactive Protein - analysis; Endocrinology & Metabolism; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; HIV Infections - blood; HIV Infections - drug therapy; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Lipids - blood; Male; Medical sciences; Middle Aged; Peroxidase - blood; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids
• ISSN: 0026-0495; 1532-8600
• DOI: 10.1016/j.metabol.2012.03.003

Abstract Objective: HIV infection is exacerbated through additional pro-atherogenic mechanisms related to the processes of immune activation, inflammation, coagulation, and the modification of lipoproteins (e.g., particles of high density lipoprotein), contributing to increased cardiovascular risk. The aim of this study was to analyze the serum concentrations of myeloperoxidase (MPO) and other laboratory parameters in HIV-infected patients treated or not with antiretroviral drugs compared to non-infected individuals. Materials/Methods: The study included 154 volunteers: 47 non-infected individuals (control group - CON), 27 infected and untreated individuals (NTARV group) and 80 treated individuals (TARV group). We analyzed the counts of CD4+ lymphocytes and the viral load of the infected patients, along with the blood count, fasting glucose, total serum cholesterol (CHOL), HDL cholesterol, LDL cholesterol, triglycerides, MPO and high-sensitivity C-reactive protein (CRP) of all study participants. Results: There were significant increases in glucose, CHOL, LDL cholesterol, and triglycerides in the TARV group and significant reductions in the levels of HDL cholesterol for the TARV and NTARV groups. Significantly elevated levels of Hs-CRP were observed only in the TARV group, while levels of MPO were significantly higher in the TARV and NTARV groups compared to the control group. A correlation of MPO with Hs-CRP ( r = 0.21, p = 0.032) was observed for HIV-infected patients, but MPO did not correlate significantly with the other analyzed parameters. Conclusions: The investigation of early biomarkers for cardiovascular risk evaluation, such as MPO, contributes to the clinical monitoring of HIV-infected individuals. The serum levels of MPO correlated with Hs-CRP and were high in HIV-infected individuals, indicating a possible predictor of cardiovascular events in these patients.