Interleukin-17 gene polymorphisms and the risk of early miscarriage: A case-control study and meta-analysis

• Published in: Meta Gene 2018-09, Vol.17, p.206-211
• Main Authors: Verma, Priyanka, Nair, Rohini R., Budhwar, Snehil, Singh, Vertika, Bala, Renu, Khanna, Anuradha, Agarwal, Nisha R., Rai, Punam, Rajender, Singh, Singh, Kiran
• Format: Article
• Language: English
• Subjects: Early miscarriage; Genotyping; Meta-analysis; Polymorphism
• ISSN: 2214-5400; 2214-5400
• DOI: 10.1016/j.mgene.2018.06.012

Previous reports clearly suggest that IL-17 have important role in development of systemic and peripheral inflammation in early miscarriage (EM). In the present study, we have investigated the association between genetic variants in IL-17A, IL-17F and susceptibility to EM. We recruited 135 EM patients and 150 controls and used PCR-RFLP method for genotyping the polymorphisms of IL-17A, rs4711998 (−832 A/G), rs8193036 (−692C/T) and IL-17F rs763780 (7488 T/C). No significant difference was observed for all the three polymorphic sites between the EM patients and control group in terms of genotypic (rs4711998, χ2 = 1.95, p = 0.37; rs8193036, χ2 = 1.91, p = 0.38; rs763780, χ2 = 2.45, p = 0.29), and allelic frequencies (rs4711998, OR = 1.19, 95% CI = 0.84 to 1.67, p = 0.35; rs8193036,OR = 1.18, 95% CI = 0.58 to 2.06, p = 0.75; rs763780, OR = 1.5, 95% CI = 0.93 to 2.71, p = 0.11). Further, meta-analysis of IL-17F (rs763780) variant with EM also revealed non-significant association of IL-17F (rs763780) variant with EM in the presence of mutant genotype (CC) via random effect model (p = 0.70, OR = 1.30, 95% CI =0.33–5.11). •The IL-17A rs4711998 and rs81936036 were not associated with early miscarriage.•The IL-17F rs763780 also demonstrated non-significant association with miscarriage.•Meta-analysis also revealed non-significant association of IL-17F rs763780 with miscarriage.