Two rivals or colleagues in the liver? Hepatit B virus and Schistosoma mansoni co-infections: A systematic review and meta-analysis

• Published in: Microbial pathogenesis 2021-05, Vol.154, p.104828, Article 104828
• Main Authors: Khatami, Alireza, Bahadory, Saeed, Ghorbani, Saied, Saadati, Hassan, Zarei, Mohammad, Soleimani, Alireza, Zibaei, Mohammad
• Format: Article
• Language: English
• Subjects: Hepatitis B; Liver complications; Meta-analysis; Schistosoma mansoni; Schistosomiasis
• ISSN: 0882-4010; 1096-1208
• DOI: 10.1016/j.micpath.2021.104828

Globally, hepatitis B and schistosomiasis (Mansoni) together affect about 300 million people; which cause hepatic disorders worldwide. Given that little is known about co-infections with hepatitis B and schistosoma mansoni, the present study investigates these two health problems alone and together and their possible correlation. A search was conducted for reports published between January 1990 and October 2020 by using Embase, Scopus, PubMed, Web of Science databases; Out of a total of 20 studies, 14 cross-sectional studies (6329 people) and 6 case-control studies (2138 individual) were reviewed. The pooled prevalence of hepatitis B virus (HBV), S.mansoni infections, and their co-infections; heterogeneity and the Odds Ratio (OR) were evaluated by Stata 11.2. Among the included studies in the inclusion criteria, the pooled prevalence of hepatitis B, S. mansoni was 34% (95% CI, 0.23–0.46), 41% (95% CI, 0.24–0.59) and their co-infections was 18% (95% CI, 0.11–0.25) by regions. The hepatitis B and S. mansoni correlation was significant in populations with schistosoma compared to control group (OR, 2.12; 95% CI, 1.36–3.30). Our results showed that in addition to the high global prevalence of hepatitis B- S. mansoni (co) infections in the included studies, there is a significant association between them, especially in people suffering from schistosoma. These results highlight the importance of integrated interventions measurements against coexistence of parasitic and viral diseases. We know that more research studies need to be done in this field and global monitoring should be considered for the co-infection of these two important complications. •Globally, hepatitis B and schistosomiasis (Mansoni) together affect about 300 million people; which cause hepatic disorders worldwide. The present study investigates these two health problems alone and together and their possible correlation.•Among the included studies in the inclusion criteria, the pooled prevalence of hepatitis B, S. mansoni was 34% (95% CI, 0.23-0.46), 41% (95% CI, 0.24-0.59) and their co-infections was 18% (95% CI, 0.11-0.25) by regions. The hepatitis B and S. mansoni correlation was significant in populations with Schistosoma infections compared to control group (OR, 2.12; 95% CI, 1.36–3.30).•Our results showed that in addition to the high global prevalence of hepatitis B- S. mansoni (co) infections, there is a significant association between them, especially in people suffering from Schistosoma.