Pottasium triiodide enhanced turn-off sensing of tyrosine in carbon dot platform

In this work, a turn-off sensing approach for simple and sensitive determination of tyrosine is developed on the basis of quenching of fluorescence of carbon dot. When carbon dot is mixed with potassium triiodide, the fluorescence of carbon dot undergo quenching and this quenching phenomena get enha...

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Bibliographic Details
Published in:Microchemical journal 2019-05, Vol.146, p.12-19
Main Authors: Nebu, John, Anu, K. Soman, Anjali Devi, J.S., Aparna, R.S., Aswathy, A.O., Lekha, G.M., Sony, George
Format: Article
Language:English
Subjects:
Amino acid
Carbon dot
Paper strip assay
Quenching
Real sample analysis
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Summary:In this work, a turn-off sensing approach for simple and sensitive determination of tyrosine is developed on the basis of quenching of fluorescence of carbon dot. When carbon dot is mixed with potassium triiodide, the fluorescence of carbon dot undergo quenching and this quenching phenomena get enhanced in the presence of tyrosine. The possible interfering amino acids and biomolecules exhibit turn-on behaviour and thus tyrosine has good selectivity. The limit of detection of tyrosine is 950 nM. Real sample analysis in serum sample shows good recovery percentage. The graphical abstract depicting the fluorescence turn off sensing of tyrosine using KI3 quenched nitrogen doped carbon dot. [Display omitted] •Nitrogen doped carbon dots shows luminescence.•Luminescence of nitrogen doped carbon dots is quenched by KI3.•KI3-tyrosine complex shows fully quenched the luminescence of nitrogen doped quantum dots.
ISSN:0026-265X
1095-9149
DOI:10.1016/j.microc.2018.12.021