Amberlite XAD-4 modified electrodes for highly sensitive electrochemical determination of nimesulide in human urine

•The electrochemical method was proposed for the determination of nimesulide•Surface characteristics of carbon paste was modified with amberlite XAD-4 resin was studied•The oxidation reaction of nimesulide investigated by using the cyclic voltammetric technique•The sensor showed the sensitive and se...

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Bibliographic Details
Published in:Microchemical journal 2020-03, Vol.153, p.104389, Article 104389
Main Authors: Shetti, Nagaraj P., Shanbhag, Mahesh M, Malode, Shweta J, Srivastava, Rajesh K, Reddy, Kakarla Raghava
Format: Article
Language:English
Subjects:
Biological samples
Electrochemical methods
Electrochemical sensor
Modified electrodes
Urine
Voltammetry
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Summary:•The electrochemical method was proposed for the determination of nimesulide•Surface characteristics of carbon paste was modified with amberlite XAD-4 resin was studied•The oxidation reaction of nimesulide investigated by using the cyclic voltammetric technique•The sensor showed the sensitive and selective nature in nimesulide determination and applications in biological and clinical real urine sample analysis A Simple technique has been developed for electrochemical oxidation and determination of nimesulide (NIM) drug-using voltammetric techniques in phosphate buffer solutions. The modified sensor showed good stability, sensibility, and enhancement in the peak current with good reproducibility. Based on the variation of parameters and their results, the heterogeneous rate constant value was also calculated. The proposed sensor can be utilized for the analysis of the drug in biological and pharmaceutical samples with good recovery values. A suitable electrooxidation mechanism was proposed. The proposed technique was successfully employed for the determination of NIM in biological samples with good recovery results. [Display omitted]
ISSN:0026-265X
1095-9149
DOI:10.1016/j.microc.2019.104389