Piperazine appended napthalimide scaffold as turn on fluorescent probe for hydrogen sulfide

• Published in: Microchemical journal 2020-09, Vol.157, p.105019, Article 105019
• Main Authors: Sureshkumar, Kempahanumakkagari, Ramakrishnappa, Thippeswamy, Samrat, Devarmane
• Format: Article
• Language: English
• Subjects: FRET; Naked eye detection; Napthalimide; Sulfide; Water samples
• ISSN: 0026-265X; 1095-9149
• DOI: 10.1016/j.microc.2020.105019

[Display omitted] •FRET based fluorimetric sensor for sulfide has been designed synthesized.•The present probe sense sulfide ions at physiological pH conditions.•The sensor is highly selective to sulfide ions in aqueous medium.•The probe can be used to monitor sulfide ions in environmental samples. The H2S specific fluorescent sensor based on FRET (Forster resonance energy transfer) was designed and synthesized. The probe was synthesized by appending 7-nitro-1, 2,3-benzoxadiazole (NBD) amine to the piperazine coupled napthalimide scaffold. The sulfide induces red color to the probe which was colorless when it is alone. Similarly when illuminate under light the aqueous solution of probe in the presence of sulfide its exhibits strong green fluorescence. The naked eye detectable color as well as fluorescent changes of the probe is highly specific to sulfide no other anions normally present in natural water like fluoride, sulfite and sulfate and biologically relevant species like cysteine, homocysteine and glutathione. The probe exhibits excellent sensitivity towards H2S i.e. linear range of about 1.0–100 µM and LOD of about 0.016 µM. The present sensor system was applied for monitoring H2S in various water samples.