Solid-phase extraction of nonsteroidal anti-inflammatory drugs in urine and water samples using acidic calix[4]arene intercalated in LDH followed by quantification via HPLC-UV

[Display omitted] •Acidic calix[4]arene (ACA) was successfully intercalated between the layers of LDH.•The LDH/ACA sorbent was used for packed sorbent extraction method.•The presented sorbent was easy to use and showed a high ability for extraction of NSAIDs.•The RSM methodology was used to optimize...

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Bibliographic Details
Published in:Microchemical journal 2022-12, Vol.183, p.107985, Article 107985
Main Authors: Shafiei-Navid, Saied, Hosseinzadeh, Rahman, Ghani, Milad
Format: Article
Language:English
Subjects:
Box–Behnken design
calixarene
Nonsteroidal anti-inflammatory drugs
Packed sorbent
Plackett–Burman design
Solid-phase extraction
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Summary:[Display omitted] •Acidic calix[4]arene (ACA) was successfully intercalated between the layers of LDH.•The LDH/ACA sorbent was used for packed sorbent extraction method.•The presented sorbent was easy to use and showed a high ability for extraction of NSAIDs.•The RSM methodology was used to optimize the experimental parameters. The aim of the present study is the preparation of a carboxylic acid calix[4]arene-based sorbent. To this end, calix[4]arene containing two carboxylic acid groups in lower rim (ACA) was successfully synthesized and then intercalated between Mg/Al layered double hydroxide (LDH) as a new sorbent (ACA-LDH). The extraction capability of the prepared sorbent was investigated by using the pack column strategy for the extraction of selected nonsteroidal anti-inflammatory drugs (NSAIDs) includes aspirin, ibuprofen and naproxen (as model compounds) from different complicated matrices, as well as ACA and LDH as a control. The successful synthesis of the sorbent was approved using 1H and 13C NMR, FT-IR spectroscopy, MAP, TGA, FE-SEM and XRD. A response surface methodology (RSM) including Plackett–Burman design (PBD) and Box–Behnken design (BBD) were used to refine and optimize parameters affecting extractionand desorption process. The extracted analytes were analyzed using a high-performance liquid chromatography equipped with UV detector (HPLC-UV). Under optimal condition, the response to NSAIDs in the concentration range of 0.5–500 μg.L−1 is linear. The intra-day and inter-day RSDs, and LODs, are 
ISSN:0026-265X
DOI:10.1016/j.microc.2022.107985