Dispersive solid-phase extraction facilitated by newly developed, fully 3D-printed device

• Published in: Microchemical journal 2023-04, Vol.187, p.108367, Article 108367
• Main Authors: Szynkiewicz, Dagmara, Georgiev, Paweł, Ulenberg, Szymon, Bączek, Tomasz, Belka, Mariusz
• Format: Article
• Language: English
• Subjects: 3D-printed analytical system; 3D-printing; Dispersive solid-phase extraction; Rapid prototyping; Sample preparation
• ISSN: 0026-265X; 1095-9149
• DOI: 10.1016/j.microc.2022.108367

[Display omitted] •Multielement extraction device for DSPE has been designed and 3D-printed.•Separation of liquid and solid fraction in DSPE is simplified and secure.•Application of DSPE is broadened from sample clean-up to actual extraction.•DSPE is proved as efficient sample preparation for LC-MS analysis.•3D printing in a laboratory allows self-sufficiency and flexibility. Dispersive solid-phase extraction (DSPE) is considered a beneficial sample preparation in comparison with traditional solid-phase extraction (SPE), mostly due to its simplicity and high recoveries. In a typical procedure, the extract has to be manually aspirated from a vessel containing a centrifuged pellet of sorbent particles. This step can lead to contamination of the chromatographic system and can cause loss of the analyte. In this paper, we propose a new design of a set of simple vessels manufactured by 3D printing that help to overcome the main drawbacks of a conventional DSPE protocol. We show that a complete analytical device can be designed, improved, manufactured, and applied within one laboratory at a low cost. The usefulness of the developed sample preparation device is demonstrated in an example of imipramine and carbamazepine extraction and compared with the performance of the conventional protocol without 3D printed parts.